PSA, Free

Specialist

also free psa

What it isThe fraction of PSA that circulates unbound to other proteins. Cancer cells produce more of the bound form, so free PSA percentage helps distinguish benign from malignant elevations.

DoesRefines PSA interpretation when total PSA is in the diagnostic gray zone.

GoodA high percentage of free PSA suggests benign causes — BPH or prostatitis.

BadA low percentage of free PSA raises concern for prostate cancer and triggers further evaluation.

Standard
% free >25% favors benign.
Optimal
>25% free (higher is good)
Modifiers
Same handling considerations as total PSA.

How to optimize

Lifestyle
Same as total PSA.
Diet
Same as total PSA.
Supplements
Same as total PSA.
Peptides
Drugs
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within Men's Hormones