Prothrombin G20210A

Specialist

also factor ii mutation, f2 g20210a

What it isA single-nucleotide variant in the 3' untranslated region of the prothrombin (Factor II) gene that raises prothrombin levels in blood. Roughly 2% of people of European ancestry carry one copy.

DoesRaises circulating prothrombin, increasing the rate of thrombin generation and shifting coagulation toward clot formation.

GoodWild-type genotype carries no excess thrombosis risk from this gene.

BadHeterozygous carriers have roughly 2–3 fold higher lifetime venous thromboembolism risk; homozygotes substantially higher. Risk compounds with estrogen, pregnancy, surgery, smoking, and other thrombophilias.

Standard

Genotype: wild-type, heterozygous, or homozygous.

Optimal

No widely-accepted optimal — the genotype is fixed; the goal is avoiding additive thrombotic triggers.

Modifiers

One-time test; genotype does not change.

How to optimize

Lifestyle: Move during long travel; compression stockings; weight management; avoid smoking; treat sleep apnea.
Diet: Adequate hydration; standard cardiovascular-healthy pattern.
Supplements: Omega-3 EPA+DHA, vitamin D3 if deficient; avoid high-dose estrogenic supplements.
Peptides: —
Drugs: Avoid combined oral contraceptives and oral estrogen therapy; perioperative thromboprophylaxis; direct oral anticoagulants after a thrombotic event.

within Genetic