eGFR (Estimated Glomerular Filtration Rate)

Routine annual

also egfr, gfr

What it isA calculated estimate of how much blood the kidneys filter per minute, derived from creatinine adjusted for age and sex.

DoesServes as the standard staging metric for chronic kidney disease.

GoodA high eGFR signals robust filtration and a wide kidney reserve, predicting longevity and tolerance of drugs cleared by the kidneys.

BadFalling eGFR signals chronic kidney disease, predicts cardiovascular events, mortality, and eventually need for dialysis.

Standard

>90 mL/min/1.73m² normal; 60–89 mildly reduced; <60 CKD.

Optimal

95–120 mL/min/1.73m² (higher is good)

Modifiers

Declines naturally with age; affected by muscle mass through creatinine.

How to optimize

Lifestyle: Manage blood pressure, control blood sugar, hydrate, avoid chronic NSAIDs, Zone 2 cardio, weight loss.
Diet: Moderate protein; plenty of vegetables; lower sodium; Mediterranean pattern.
Supplements: Omega-3 EPA+DHA (2–4g/day), CoQ10 (100–200mg/day).
Peptides: —
Drugs: ACE inhibitors, ARBs, SGLT2 inhibitors, finerenone for kidney protection.

within Kidney