DHEA-Sulfate (DHEA-S)

Advanced wellness

also dehydroepiandrosterone sulfate

What it isDHEA-S is the most abundant circulating steroid in the body, produced primarily by the adrenal glands. It serves as a reservoir from which sex hormones can be synthesized.

DoesProvides substrate for both androgen and estrogen pathways; supports immune, mood, libido, and bone density.

GoodHigh-normal DHEA-S signals strong adrenal output and tracks biological youth.

BadLow DHEA-S correlates with chronological aging, chronic stress, and frailty. Very high DHEA-S in women suggests PCOS or adrenal androgen excess.

Standard

Age- and sex-dependent; men 30s ~250–500 µg/dL.

Optimal

400–550 µg/dL men 30s, 250–380 µg/dL women 30s, age-adjusted (higher is good within range)

Modifiers

Declines with age (the steepest aging marker); falls with chronic stress and inflammation.

How to optimize

Lifestyle: Stress management; sleep; resistance training; sun exposure.
Diet: Adequate calories and healthy fats; cholesterol is the substrate.
Supplements: DHEA supplementation (25–50mg/day in adults with low levels, under monitoring), ashwagandha, pregnenolone.
Peptides: —
Drugs: Prescription DHEA available in some jurisdictions.

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