Deamidated Gliadin Peptide (DGP)

What it isAntibodies (IgA or IgG) targeting deamidated gliadin, a fragment of gluten that has been chemically modified by tissue transglutaminase.

DoesDetects celiac disease, particularly useful in IgA-deficient patients where tTG-IgA can give false negatives.

GoodNegative result alongside other celiac markers argues against the disease.

BadPositive DGP-IgG is especially valuable in IgA deficiency and in young children.